NeoGen EVO › The Science
Explore the Science

NeoGen EVO, in depth.

NeoGen EVO is nitrogen plasma skin regeneration — a clinical, practitioner-led treatment that works beneath the surface to renew skin from within. Explore exactly how it works, who it suits, and how to prepare and recover.

The concerns

What NeoGen treats

Plasma is genuinely versatile — it is cleared for several medical indications and supports a wide range of skin-quality concerns. Here is everything it addresses, with the science behind each.

Acne Scarring

Good evidence

How plasma remodels the dermis to soften atrophic acne scars

Plasma delivers controlled thermal energy into the dermis, stimulating a wave of new collagen that gradually fills and softens depressed scars from below.

Acne scars form when inflammation damages the dermal collagen scaffold, leaving the surface tethered and depressed. Plasma heats the dermis without removing the surface, triggering the skin's own remodelling response — fibroblasts lay down fresh collagen along the line of cleavage between the treated zones.

Because the intact epidermis is preserved as a natural dressing, healing is more controlled than with fully ablative resurfacing, which matters on skin already marked by scarring.

Evidence — Measured collagen renewal
  • Histology following plasma treatment shows a band of new collagen at the dermo-epidermal junction, with measurable new-collagen depth and continued remodelling beyond 90 days.
  • Boxcar and rolling scars typically respond better than narrow icepick scars; a course produces progressive improvement.
Bogle MA, Arndt KA, Dover JS. Arch Dermatol, 2007. Foster KW et al. on plasma resurfacing.
What to expect
  • Sessions: Often a course of 2–4, spaced several weeks apart, depending on scar depth.
  • Downtime: Typically 5–10 days for higher-energy settings used on scarring.
  • Timeline: Softening builds over weeks to months as collagen matures.

Actinic Keratosis

Cleared medical indication

How and why plasma addresses sun-induced pre-cancerous lesions

Actinic keratosis is a pre-cancerous condition. Any lesion must be properly medically diagnosed and assessed before treatment — it is never treated on assumption, and monitoring is a medical decision. This page is for education, not diagnosis.

Plasma delivers a controlled thermal pulse that causes the affected patches to flake away from beneath, while the intact outer skin stays in place as a natural protective dressing.

Rather than targeting a single pigment or vessel, plasma deposits energy evenly across the whole surface. The sun-damaged cells are thermally modified and shed during healing.

Crucially, biopsies show the underlying skin itself improves — not just the visible lesion — which is what makes plasma interesting for field sun-damage as well as discrete lesions.

Evidence — It improves the underlying skin
  • In peer-reviewed work, punch biopsies taken 90 days after treatment showed increased epidermal thickening, decreased solar elastosis (the underlying sun-damage), and new collagen deposition in the upper dermis.
  • Actinic keratosis is among the device's cleared indications.
Bogle MA, Arndt KA, Dover JS. Arch Dermatol, 2007. Cited histological findings on photodamaged skin.
What to expect
  • Sessions: Varies by lesion and energy level — determined medically.
  • Downtime: Low-energy 3–4 days; higher-energy 5–10 days.
  • Healing: The surface stays intact and sheds naturally; results build over weeks.

Seborrheic Keratosis

Cleared medical indication

How plasma treats these benign, raised "stuck-on" growths

⚠ Any new, changing, or uncertain skin lesion should be assessed by an appropriate medical professional before treatment, to confirm it is benign.

Plasma delivers thermal energy that sublimates the raised lesion tissue layer by layer, allowing it to dry, darken and shed as the skin beneath renews.

Seborrheic keratoses are benign growths that sit on the skin surface and can look waxy or "stuck on". Plasma treats them without a scalpel or freezing, thermally modifying the lesion so it desiccates and flakes away over the following days.

Because the treatment is non-contact and the surrounding skin is preserved, it can be a refined option for these lesions, including in cosmetically sensitive areas.

Evidence — What the research shows
  • Seborrheic keratosis is among the device's cleared indications, and plasma is well documented for superficial lesion removal.
Cleared indication; plasma skin regeneration literature on superficial lesions.
What to expect
  • Sessions: Often one treatment per lesion, occasionally more for thicker growths.
  • Downtime: A small scab forms and sheds over roughly 1–2 weeks.
  • Healing: Keep the area protected while it renews; avoid picking.

Pigmented & Superficial Lesions

Cleared medical indication

How plasma addresses superficial pigmented marks and lesions

⚠ Any pigmented lesion that is new, changing, irregular or uncertain must be medically assessed before any treatment, to exclude anything that needs different management.

Plasma thermally modifies superficial pigmented and benign lesions so they shed during healing, while the intact surface protects the skin beneath.

Superficial pigmented lesions and certain benign marks can be treated by plasma's controlled surface energy. The treated tissue desiccates and flakes away as fresh skin forms.

Plasma is not pigment-selective like some lasers, which is part of why a careful assessment of the lesion type matters before treatment.

Evidence — What the research shows
  • Superficial skin lesions (including certain pigmented lesions) are among the device's cleared indications.
Cleared indication; plasma skin regeneration literature.
What to expect
  • Sessions: Often one to a few, depending on the lesion.
  • Downtime: Light flaking or a small scab over several days to two weeks.
  • Healing: Protect from sun while the area renews.

Wrinkles & Fine Lines

Cleared medical indication

How plasma softens rhytides, including the delicate eye area

Plasma heats the dermis to stimulate fresh collagen and elastin, smoothing the skin's surface and softening fine lines and deeper rhytides over time.

Lines deepen as the dermal collagen and elastin scaffold weakens. Plasma's thermal energy prompts a remodelling response — new collagen is laid down, thickening and firming the skin so lines soften from within.

Because the epidermis is preserved, plasma can be used around the eyes and other delicate areas where the skin is thin.

Evidence — Measured wrinkle reduction
  • A low-energy three-treatment study found a 37% reduction in facial rhytids at three months, with 68% patient-rated improvement in overall appearance; another reported a 39% reduction in fine-line depth at six months.
  • Histology confirms new collagen and continued improvement beyond a year.
Bogle 2007 (Arch Dermatol); Potter et al. on fine-line depth.
What to expect
  • Sessions: A series for fine lines (low energy), or fewer higher-energy treatments for deeper lines.
  • Downtime: 3–4 days (low energy) up to 7–10 days (high energy).
  • Timeline: Progressive smoothing over 3–6 months and beyond.

Skin Laxity & Firmness

Good evidence

How plasma firms and tightens through collagen renewal

By heating the dermis and driving neocollagenesis, plasma thickens and firms the skin, gradually improving mild laxity and restoring a tauter quality.

Skin loosens as collagen and elastin decline. Plasma's controlled thermal injury stimulates fibroblasts to build new collagen, which firms and tightens the skin over the months that follow.

It is best suited to mild-to-moderate laxity and skin-quality firming rather than significant sagging, which may need different approaches.

Evidence — What the research shows
  • Plasma histology shows new collagen formation and continued dermal remodelling; clinical reports note improved skin tightness and tone, with high-energy single-pass studies showing tone improvement at 30 days.
Kilmer et al.; Bogle 2007 histology.
What to expect
  • Sessions: Tailored to your skin — often a course or periodic higher-energy treatments.
  • Downtime: Varies with energy, from a few days to around 10.
  • Timeline: Firming builds gradually, peaking at 3–6 months.

Sun Damage & Photoageing

Good evidence

How plasma renews sun-damaged, weathered skin

Plasma treats the whole skin surface, shedding sun-damaged cells and rebuilding the dermis — improving tone, texture and the deeper signs of sun damage together.

Years of sun exposure break down collagen (solar elastosis) and leave uneven tone and rough texture. Plasma addresses this as a field treatment, renewing the surface while stimulating dermal repair beneath.

The non-fractionated approach means the whole area is treated evenly, with no untreated islands.

Evidence — Reduced solar elastosis
  • Biopsies at 90 days show decreased solar elastosis and new collagen, alongside clinical improvement in photodamaged skin of the face, neck, chest and hands of around 50% in studies on photoageing.
Bogle 2007; plasma photoageing literature.
What to expect
  • Sessions: A course or periodic treatments depending on severity.
  • Downtime: A few days to around 10, by energy level.
  • Timeline: Tone and texture improve over weeks to months.

Crepey Skin (Eyes & Neck)

Good evidence

How plasma renews thin, crinkled skin where it shows most

Plasma is particularly suited to thin, crepey skin — it renews the surface and rebuilds collagen while keeping the delicate epidermis intact as a protective layer.

Crepey skin around the eyes and on the neck is thin and finely wrinkled, with depleted collagen. Plasma renews this skin without removing the surface, which is why it can be used safely on these delicate areas.

New collagen thickens the skin, reducing the crinkled, papery quality over the following months.

Evidence — What the research shows
  • The periorbital area and neck are recognised strengths of plasma; histology supports new collagen and epidermal renewal in thin skin.
Plasma periorbital and neck literature; Bogle 2007 histology.
What to expect
  • Sessions: Often a series, tailored to the area and skin thinness.
  • Downtime: A few days for lower-energy eye-area work; longer for higher energy.
  • Timeline: Skin quality improves gradually over months.

Active Acne

Emerging evidence

Where plasma fits in managing mild-to-moderate active acne

Plasma's thermal energy can reduce certain acne-causing activity and improve skin in mild-to-moderate cases, though it is usually a supporting option rather than first-line.

Plasma generates heat that can affect sebaceous activity and the skin environment. Some reports describe improvement in active acne, but it is not a primary acne therapy.

For most people, active acne is best managed medically first, with plasma considered for the skin quality and scarring that acne leaves behind.

Evidence — What the research shows
  • Evidence for plasma in active acne is limited and emerging; it is better established for acne scarring and skin renewal.
Emerging plasma acne literature.
What to expect
  • Sessions: Considered case by case, often alongside other measures.
  • Downtime: Varies by energy level.
  • Timeline: Best assessed individually.

Redness & Rosacea

Emerging evidence

Why plasma is not a primary vascular treatment, and where it may help

⚠ Plasma is not vascular-selective and is not a primary treatment for rosacea or thread veins. Gentler, vessel-targeted options are usually more appropriate — we'll advise honestly.

Plasma does not selectively target blood vessels, so it is not a first-line treatment for redness, rosacea or thread veins; other modalities are usually preferred.

Redness from rosacea and thread veins comes from dilated blood vessels, which are best addressed by vessel-selective treatments rather than plasma's broad thermal energy.

Plasma may improve overall skin quality in some rosacea-prone skin, but expectations should be realistic and it is rarely the primary choice for redness.

Evidence — What the research shows
  • Plasma is not a recognised vascular-selective treatment; the evidence base for redness and rosacea is limited.
Plasma is non-vascular-selective; general dermatology guidance.
What to expect
  • Sessions: Rarely indicated for redness alone.
  • Downtime: Not applicable as a primary redness treatment.
  • Timeline: We'll usually suggest more suitable options.

Stretch Marks

Emerging evidence

Where plasma may help remodel stretch-marked skin

Plasma can stimulate dermal collagen in stretch-marked skin, which may improve texture and appearance, though the evidence here is more limited than for other concerns.

Stretch marks are areas where the dermis has torn and healed with altered collagen. Plasma's remodelling response may improve the texture and quality of these areas over a course.

Results vary, and stretch marks are among the harder concerns to treat with any modality — honesty about expectations is important.

Evidence — What the research shows
  • Evidence for plasma on stretch marks is limited and emerging; collagen-remodelling rationale applies, but outcomes vary.
Emerging plasma literature; collagen-remodelling rationale.
What to expect
  • Sessions: A course, with realistic, individualised expectations.
  • Downtime: Varies by energy and area.
  • Timeline: Gradual textural change over months, where it responds.
Before treatment

Preparing your skin

Well-prepared, well-hydrated skin heals more predictably and gives a better result. Here is how to get ready in the weeks and days beforehand.

FirstYour history

Discuss your medical history

  • Tell us if you've used acne or wrinkle-relaxing treatments in the last 6 months.
  • Mention any history of keloid scarring or cold sores.
  • Tell us about any medications, allergies, or skin sensitivities.
  • Flag any recent injectables or other treatments.
Before3 weeks

Protect from the sun

  • Avoid excessive sun exposure and all tanning for at least three weeks.
  • Apply a broad-spectrum SPF 30+ daily to areas to be treated.
  • No fake tan or self-tan on the treatment area.
Before1 week

Ease off the actives

  • Stop exfoliating acids, scrubs and retinoids in the week before.
  • Keep your routine gentle and barrier-supporting.
Before5 days

Hydrate, inside and out

  • Moisturise day and night with a gentle, unperfumed moisturiser.
  • Drink plenty of water; plasma's heat travels through the skin's own moisture.
  • For higher-energy treatments, obtain any prescribed medication and use as directed.
It isn't an afterthought

NeoGen deposits its energy at the surface, and that heat travels through the skin's own moisture. Well-hydrated skin carries it evenly and predictably — which is exactly why the water and moisturiser in the days before make a real difference to your comfort and your result.

After treatment

Caring for your skin

NeoGen leaves the surface intact — the treated skin becomes its own natural dressing while fresh skin forms beneath. Your job now is simple: let it work. Recovery depends on the energy used, so find your level below.

Low energy

2–4 days · minimal peeling

  • Keep the skin dry; if mild irritation lingers, pat gently with cool water.
  • Don't cleanse for 24 hours, then use a mild cleanser.
  • Once peeling is nearly done, rehydrate with a mild moisturiser.

Mid energy

2–5 days · flaking & peeling

  • Rehydrate only once peeling is nearly complete — too soon delays it.
  • Use any barrier cream or gel you're given.
  • Follow the same gentle care as low energy.

High energy

7–10 days · fuller peeling

  • A barrier cream may keep skin moist — remove gently after 24 hours, or as advised.
  • You may cleanse and reapply twice daily for a few days.
  • Follow the same care throughout.
The golden rules
  • Let it peel on its own — never pick or pull the flaking skin.
  • Don't moisturise while actively peeling — it delays healing.
  • Keep the treated skin out of the sun.
  • No harsh or exfoliating products, scrubs or strong actives.
  • Try not to touch the area, except to cleanse or reapply barrier cream.
  • Don't wear anything that rubs or irritates the treated skin.
  • After a facial treatment, sleep slightly raised and change bedding daily.
  • Take any prescribed medication exactly as directed.
Important information

Is it right for you?

NeoGen is safe and effective for most people, but like any clinical treatment there are situations where it isn't suitable or needs discussing first. Nothing here rules you out automatically — it simply tells us what to talk through at your consultation.

Not suitable

When NeoGen can't go ahead

For your safety, treatment isn't possible in these situations.

  • Pregnancy, nursing, or IVF treatment
  • Pacemakers, ICDs or electronic implants
  • An active infection or skin infection in the area
  • A current cancer diagnosis or treatment
  • Generally unwell or unfit for minor procedures
Discuss first

Conditions we'll talk through

These don't necessarily prevent treatment, but we need to know about them.

  • Auto-immune conditions
  • Heart conditions
  • A tendency to keloid or raised scarring
  • Vitiligo or other pigment conditions
  • Blood-clotting or bleeding disorders
  • Roaccutane (isotretinoin) in the last 6 months
  • Cold sores / herpes simplex history
  • Regular medications — steroids, blood thinners, NSAIDs
Manage beforehand

Sort these before your appointment

Easily managed with a little planning ahead of treatment.

  • No sun exposure or tanning — 3 weeks before
  • No fake tan / self-tan on the area
  • Recent injectables — allow time between
  • Pause active skincare (retinol, acids) — 5 days before

This is a guide to help you prepare — it isn't a diagnosis, and it isn't exhaustive. Your full medical history is always reviewed at consultation, where suitability is confirmed for you personally.

Begin with a consultation

Every NeoGen journey starts with a proper assessment of your skin and history, so we can tailor the right plan and energy level for you.

Book a Consultation Back to NeoGen
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